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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STX1A All Species: 31.52
Human Site: S200 Identified Species: 53.33
UniProt: Q16623 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q16623 NP_004594.1 288 33023 S200 S E I E T R H S E I I K L E N
Chimpanzee Pan troglodytes XP_001146754 288 33051 S200 S E I E T R H S E I I K L E N
Rhesus Macaque Macaca mulatta NP_001028037 288 32987 S200 S E I E T R H S E I I K L E N
Dog Lupus familis XP_849756 293 33456 S205 S E I E T R H S E I I K L E N
Cat Felis silvestris
Mouse Mus musculus O35526 288 33036 S200 S E I E T R H S E I I K L E T
Rat Rattus norvegicus P32851 288 33049 S200 S E I E T R H S E I I K L E N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001233551 316 35842 S228 N E I E T R H S E I I K L E N
Frog Xenopus laevis NP_001086322 286 32704 R198 S E I E S R H R D I V R L E S
Zebra Danio Brachydanio rerio NP_571598 288 33347 T199 N E I E T R H T E I I K L E N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24547 291 33630 Q203 A D I E A R H Q D I M K L E T
Honey Bee Apis mellifera XP_393760 291 33455 A204 A D I E A R H A D I I K L E N
Nematode Worm Caenorhab. elegans O16000 291 33234 N201 A D I E A R H N D I M K L E S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SRV7 306 34701 R211 T L A E I Q E R H D A V R D L
Baker's Yeast Sacchar. cerevisiae P39926 295 33715 A199 T A L A E V Q A R H Q E L L K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93 98.9 93.1 N.A. 98.2 98.6 N.A. N.A. 85.7 67.3 82.9 N.A. 70 69.4 63.2 N.A.
Protein Similarity: 100 95.4 98.9 94.5 N.A. 98.9 99.3 N.A. N.A. 89.8 85.7 93.4 N.A. 83.1 81.4 80 N.A.
P-Site Identity: 100 100 100 100 N.A. 93.3 100 N.A. N.A. 93.3 60 86.6 N.A. 53.3 66.6 53.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 100 N.A. N.A. 100 93.3 100 N.A. 80 93.3 93.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 23.2 24.4 N.A.
Protein Similarity: N.A. N.A. N.A. 51.3 47.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 8 8 8 22 0 0 15 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 22 0 0 0 0 0 0 29 8 0 0 0 8 0 % D
% Glu: 0 65 0 93 8 0 8 0 58 0 0 8 0 86 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 86 0 8 8 0 0 0 0 0 % H
% Ile: 0 0 86 0 8 0 0 0 0 86 65 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 79 0 0 8 % K
% Leu: 0 8 8 0 0 0 0 0 0 0 0 0 93 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 15 0 0 0 0 % M
% Asn: 15 0 0 0 0 0 0 8 0 0 0 0 0 0 58 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 8 8 8 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 86 0 15 8 0 0 8 8 0 0 % R
% Ser: 50 0 0 0 8 0 0 50 0 0 0 0 0 0 15 % S
% Thr: 15 0 0 0 58 0 0 8 0 0 0 0 0 0 15 % T
% Val: 0 0 0 0 0 8 0 0 0 0 8 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _